Nick Lewis is a staff writer for How-To Geek. If you've lost your manual, that isn't a significant problem - you can easily check what motherboard you have and then find the manual on the manufacturer's website. If you don't know what key to press, and you aren't told which key when your computer is booting up, consult the manual for your computer or motherboard. Generally, tapping the F2, Del, or F8 key will bring up a screen that'll let you pick your boot device, but it could be a different key. This process varies between computers and motherboard manufacturers. You need to change it from that drive to the new, bootable USB drive you just created with Rufus. Related: How to Boot Your Computer From a Disc or USB Drive Typically, your computer boots from the hard drive or solid-state drive that Windows is installed on. Next, you need to restart your computer and change the boot order. It will take a few minutes at least, especially if you're using an older flash drive. After that you just need to wait for Rufus to actually make the bootable media.